The most recent regular-season meeting between the Kansas City Chiefs and Arizona Cardinals took place on September 11, 2022, at State Farm Stadium in Glendale, Arizona. Kansas City won 44–21, producing 488 total yards compared with Arizona’s 282. The Chiefs led 37–7 after three quarters before the Cardinals scored twice in the fourth.
Because the teams have not met since that game, the match-player statistics below refer to the 2022 Chiefs vs. Cardinals game, while the recent-form and career sections use the latest verified statistics available.
Key Statistics
Kansas City Chiefs vs Arizona Cardinals — Team Statistics
| Statistic | Kansas City Chiefs | Arizona Cardinals |
|---|---|---|
| Final Score | 44 | 21 |
| First Downs | 33 | 18 |
| Total Yards | 488 | 282 |
| Passing Yards | 360 | 179 |
| Rushing Yards | 128 | 103 |
| Total Plays | 70 | 61 |
| Yards per Play | 7.0 | 4.6 |
| Turnovers | 1 | 0 |
| Penalties | 3 | 5 |
| Penalty Yards | 25 | 49 |
| Time of Possession | 34:42 | 25:18 |
| Third-Down Efficiency | 7/13 | 5/15 |
| Sacks | 2 | 0 |
| Points | 44 | 21 |
Kansas City controlled the game statistically, particularly through the passing game. The Chiefs generated 360 passing yards and 128 rushing yards, while Arizona finished with 179 passing yards and 103 rushing yards.
Top Player Statistics
| Player | Team | Passing | Rushing | Receiving | TD |
|---|---|---|---|---|---|
| Patrick Mahomes | KC | 30/39, 360 yds | 3-5 | — | 5 pass TD |
| Kyler Murray | ARI | 22/34, 193 yds | 5-29 | — | 2 pass TD |
| Travis Kelce | KC | — | — | 8-121 | 1 |
| Clyde Edwards-Helaire | KC | — | 7-42 | 3-32 | 2 |
| Isiah Pacheco | KC | — | 12-62 | — | 1 |
| JuJu Smith-Schuster | KC | — | — | 6-79 | 0 |
| Greg Dortch | ARI | — | — | 7-63 | 0 |
| Marquise Brown | ARI | — | — | 4-43 | 1 |
| Zach Ertz | ARI | — | — | 2-14 | 1 |
| James Conner | ARI | — | 10-26 | 5-29 | 1 rushing |
Mahomes posted a 144.2 passer rating, completing 30 of 39 attempts for 360 yards and five touchdowns without an interception.
Career Overview
The Kansas City Chiefs and Arizona Cardinals are NFL franchises with a long regular-season history. Their matchup history includes meetings involving the Cardinals under their previous St. Louis and Phoenix identities.
The series has been heavily tilted toward Kansas City. Pro Football Reference lists 14 regular-season meetings, with the Chiefs holding a 10–3–1 record against the Cardinals, including a 357–205 scoring advantage. There have been no playoff meetings between the franchises.
The September 11, 2022 meeting was the latest matchup and produced the largest combined score between the teams, with 65 total points.
2022 Matchup Profile
| Category | Kansas City | Arizona |
|---|---|---|
| Record entering game | 0–0 | 0–0 |
| Final record after game | 1–0 | 0–1 |
| Head Coach | Andy Reid | Kliff Kingsbury |
| Starting QB | Patrick Mahomes | Kyler Murray |
| Venue | State Farm Stadium | State Farm Stadium |
| Attendance | 63,697 | 63,697 |
| Result | W, 44–21 | L, 21–44 |
The Chiefs opened the game with two touchdowns in the first quarter and never surrendered the lead.
Career Statistics
For a matchup article, career statistics are most useful for the principal players involved. The following table provides verified career passing figures for Patrick Mahomes through the 2025 season.
Patrick Mahomes Career Passing
| Season | Games | Comp | Att | Yards | TD | INT | Rating |
|---|---|---|---|---|---|---|---|
| 2017 | 1 | 22 | 35 | 284 | 0 | 1 | 76.4 |
| 2018 | 16 | 383 | 580 | 5,097 | 50 | 12 | 113.8 |
| 2019 | 14 | 319 | 484 | 4,031 | 26 | 5 | 105.3 |
| 2020 | 15 | 390 | 588 | 4,740 | 38 | 6 | 108.2 |
| 2021 | 17 | 436 | 658 | 4,839 | 37 | 13 | 98.4 |
| 2022 | 17 | 435 | 648 | 5,250 | 41 | 12 | 105.2 |
| 2023 | 16 | 401 | 597 | 4,183 | 27 | 14 | 92.6 |
| 2024 | 16 | 392 | 581 | 3,928 | 26 | 11 | 93.5 |
| 2025 | 14 | 315 | 502 | 3,587 | 22 | 11 | 89.6 |
| Career | 126 | 3,093 | 4,673 | 35,939 | 267 | 85 | 100.8 |
NFL’s official career statistics list Mahomes at 35,939 passing yards and 267 touchdown passes through 2025.
Mahomes Rushing Career
| Category | Career |
|---|---|
| Games | 126 |
| Attempts | 496 |
| Rushing Yards | 2,665 |
| Average | 5.4 |
| Long | 33 |
| Rushing TD | 19 |
Season-by-Season Stats
Kansas City Chiefs vs Arizona Cardinals — Recent Meetings
| Year | Date | Winner | Score |
|---|---|---|---|
| 2002 | Dec. 1 | Kansas City | KC 49–0 ARI |
| 2006 | Oct. 8 | Kansas City | KC 23–20 ARI |
| 2010 | Nov. 21 | Kansas City | KC 31–13 ARI |
| 2014 | Dec. 7 | Arizona | ARI 17–14 KC |
| 2018 | Nov. 11 | Kansas City | KC 26–14 ARI |
| 2022 | Sept. 11 | Kansas City | KC 44–21 ARI |
The complete modern matchup record confirms that Kansas City won five of the six meetings from 2002 through 2022, with Arizona’s only victory in that span coming in 2014.
2022 Game Player Stats — Passing
| Player | Cmp | Att | Yards | TD | INT | Rating |
|---|---|---|---|---|---|---|
| Patrick Mahomes | 30 | 39 | 360 | 5 | 0 | 144.2 |
| Kyler Murray | 22 | 34 | 193 | 2 | 0 | 99.3 |
| Trace McSorley | 2 | 4 | 12 | 0 | 0 | 56.2 |
2022 Game Player Stats — Rushing
| Player | Team | Attempts | Yards | Average | TD | Long |
|---|---|---|---|---|---|---|
| Isiah Pacheco | KC | 12 | 62 | 5.2 | 1 | 22 |
| Clyde Edwards-Helaire | KC | 7 | 42 | 6.0 | 0 | 18 |
| Jerick McKinnon | KC | 4 | 22 | 5.5 | 0 | 18 |
| Kyler Murray | ARI | 5 | 29 | 5.8 | 0 | 21 |
| Eno Benjamin | ARI | 4 | 28 | 7.0 | 0 | 16 |
| James Conner | ARI | 10 | 26 | 2.6 | 1 | 8 |
| Trace McSorley | ARI | 3 | 20 | 6.7 | 0 | 14 |
2022 Game Player Stats — Receiving
| Player | Team | Targets | Receptions | Yards | TD | Long |
|---|---|---|---|---|---|---|
| Travis Kelce | KC | 9 | 8 | 121 | 1 | 35 |
| JuJu Smith-Schuster | KC | 8 | 6 | 79 | 0 | 20 |
| Clyde Edwards-Helaire | KC | 3 | 3 | 32 | 2 | 25 |
| Jerick McKinnon | KC | 4 | 3 | 27 | 0 | 18 |
| Skyy Moore | KC | 1 | 1 | 30 | 0 | 30 |
| Marquez Valdes-Scantling | KC | 4 | 4 | 44 | 0 | 17 |
| Greg Dortch | ARI | 9 | 7 | 63 | 0 | 24 |
| Marquise Brown | ARI | 6 | 4 | 43 | 1 | 26 |
| Zach Ertz | ARI | 4 | 2 | 14 | 1 | 8 |
| A.J. Green | ARI | 4 | 2 | 13 | 0 | 8 |
| Eno Benjamin | ARI | 4 | 3 | 33 | 0 | 22 |
Records
Chiefs vs Cardinals Series Records
| Category | Record |
|---|---|
| Total meetings | 14 |
| Chiefs wins | 10 |
| Cardinals wins | 3 |
| Ties | 1 |
| Chiefs win percentage | .750 |
| Chiefs points | 357 |
| Cardinals points | 205 |
| Playoff meetings | 0 |
| Latest meeting | Sept. 11, 2022 |
| Latest result | Chiefs 44–21 |
| Largest Chiefs victory | 49–0 in 2002 |
| Highest-scoring meeting | 44–21 in 2022, 65 points |
Individual Game Milestones
- Patrick Mahomes threw five touchdown passes against Arizona in 2022.
- Mahomes completed 30 of 39 passes for 360 yards.
- His 144.2 passer rating was the highest of any quarterback in the game.
- Travis Kelce recorded 121 receiving yards, the highest receiving total in the matchup.
- Kansas City produced 488 total yards.
- The Chiefs held Arizona to 282 total yards.
- Kansas City led 37–7 after three quarters.
Awards and Honors
The principal players associated with the matchup have accumulated significant NFL honors.
Patrick Mahomes
| Honor | Achievement |
|---|---|
| NFL MVP | 2018, 2022 |
| Super Bowl MVP | Super Bowl LIV, LVII, LIX |
| Super Bowl champion | Multiple championships |
| Pro Bowl | Multiple selections |
| First-team All-Pro | Multiple selections |
Travis Kelce
Kelce has been a multiple-time Pro Bowl and All-Pro selection and became one of the NFL’s most productive receiving tight ends. NFL statistics list him with 1,080 receptions, 13,002 receiving yards and 82 receiving touchdowns through the latest career data displayed by Pro Football Reference.
Performance Trends
Mahomes’ Performance in the 2022 Matchup
Mahomes’ 2022 Arizona performance stood out for efficiency and scoring production:
- 30 completions
- 39 attempts
- 360 yards
- 5 touchdowns
- 0 interceptions
- 144.2 passer rating
- 9.2 yards per attempt
The performance represented one of the strongest games of his 2022 regular season. His five touchdown passes also marked the sixth five-touchdown game of his career at that point.
Kansas City’s Offensive Distribution
The Chiefs did not rely on a single receiver. Kelce led the team with 121 yards, while Smith-Schuster added 79, Valdes-Scantling had 44, Edwards-Helaire had 32 receiving yards and McKinnon added 27.
That distribution helped Kansas City reach 488 total yards and score 44 points.
Arizona’s Offensive Pattern
Arizona’s passing attack generated 193 yards from Murray, with Greg Dortch leading the Cardinals in receptions and yards. Brown and Ertz supplied the two receiving touchdowns, but both came during the fourth quarter after Kansas City had built a 37–7 advantage.
Historical Context
The Chiefs have historically held the advantage in this matchup. Across 14 regular-season meetings, Kansas City has won 10, Arizona has won three and the teams have tied once. The Chiefs also hold a 357–205 aggregate scoring advantage.
The historical series includes a particularly dominant Kansas City performance in 2002, when the Chiefs defeated the Cardinals 49–0. The 2022 game was different in its statistical profile: Kansas City won by 23 points but Arizona still scored 21, producing the matchup’s highest combined total of 65 points.
The series began in the modern NFL era in 1970 with a 6–6 tie. Kansas City subsequently won the next three meetings before Arizona recorded its first victory in the series in 1986.
Historical Head-to-Head Results
| Date | Result |
|---|---|
| Nov. 22, 1970 | Tie, 6–6 |
| Dec. 1, 1974 | KC 17–13 |
| Nov. 23, 1980 | KC 21–13 |
| Oct. 2, 1983 | KC 38–14 |
| Nov. 23, 1986 | ARI 23–14 |
| Oct. 1, 1995 | KC 24–3 |
| Nov. 29, 1998 | KC 34–24 |
| Oct. 21, 2001 | ARI 24–16 |
| Dec. 1, 2002 | KC 49–0 |
| Oct. 8, 2006 | KC 23–20 |
| Nov. 21, 2010 | KC 31–13 |
| Dec. 7, 2014 | ARI 17–14 |
| Nov. 11, 2018 | KC 26–14 |
| Sept. 11, 2022 | KC 44–21 |
Head-to-Head Statistics
The Chiefs lead the all-time regular-season series 10–3–1. Arizona’s franchise records list the same matchup from the Cardinals’ perspective as 3–10–1.
| Head-to-Head Category | Chiefs | Cardinals |
|---|---|---|
| Wins | 10 | 3 |
| Losses | 3 | 10 |
| Ties | 1 | 1 |
| Win Percentage | 75.0% | 25.0% |
| Points Scored | 357 | 205 |
| Average Points/Game | 25.5 | 14.6 |
| Playoff Wins | 0 | 0 |
| Playoff Meetings | 0 | 0 |
Last Six Meetings
| Season | Chiefs | Cardinals | Winner |
|---|---|---|---|
| 2002 | 49 | 0 | Chiefs |
| 2006 | 23 | 20 | Chiefs |
| 2010 | 31 | 13 | Chiefs |
| 2014 | 14 | 17 | Cardinals |
| 2018 | 26 | 14 | Chiefs |
| 2022 | 44 | 21 | Chiefs |
Kansas City has won five of the six most recent meetings, with Arizona’s 2014 victory the exception.
Recent Form
The latest completed NFL season provides the most recent full-season context for both franchises.
Kansas City Chiefs — 2025
| Category | 2025 |
|---|---|
| Record | 6–11 |
| AFC West finish | 3rd |
| Points scored | 362 |
| Points per game | 21.3 |
| Points allowed | 328 |
| Points allowed/game | 19.3 |
The Chiefs missed the playoffs in 2025 after finishing 6–11. Their defense allowed 328 points, ranking sixth in the NFL by points allowed.
Patrick Mahomes finished the 2025 regular season with 3,587 passing yards, 22 touchdowns and 11 interceptions in 14 games, according to NFL career statistics.
Arizona Cardinals — 2025
| Category | 2025 |
|---|---|
| Record | 3–14 |
| NFC West finish | 4th |
| Points scored | 355 |
| Points per game | 20.9 |
| Points allowed | 488 |
| Points allowed/game | 28.7 |
Arizona finished 3–14 in 2025, allowing 488 points. The Cardinals used both Kyler Murray and Jacoby Brissett at quarterback during the season.
The current 2026 season is underway, so 2025 remains the latest completed season for full-season statistical comparison. The 2022 Chiefs-Cardinals matchup remains the latest regular-season head-to-head game between these franchises.
Statistical Highlights
- 44–21: Kansas City’s final score in the latest Chiefs-Cardinals meeting.
- 360: Patrick Mahomes’ passing yards.
- 5: Mahomes’ touchdown passes.
- 144.2: Mahomes’ passer rating.
- 121: Travis Kelce’s receiving yards.
- 8: Kelce receptions.
- 62: Isiah Pacheco’s rushing yards.
- 488: Kansas City’s total yards.
- 282: Arizona’s total yards.
- 193: Kyler Murray’s passing yards.
- 63: Greg Dortch’s receiving yards.
- 65: Combined points in the 2022 matchup.
- 10–3–1: Kansas City’s all-time regular-season record against Arizona.
- 49–0: Chiefs’ largest victory in the series, recorded in 2002.
Frequently Asked Questions
What was the Kansas City Chiefs vs Arizona Cardinals final score?
The Chiefs defeated the Cardinals 44–21 on September 11, 2022, at State Farm Stadium.
Who was the best player in Chiefs vs Cardinals?
Patrick Mahomes was the standout player. He completed 30 of 39 passes for 360 yards and five touchdowns, finishing with a 144.2 passer rating.
How many touchdowns did Patrick Mahomes throw against the Cardinals?
Mahomes threw five touchdown passes in the 2022 matchup and did not throw an interception.
How did Kyler Murray perform against the Chiefs?
Murray completed 22 of 34 passes for 193 yards and two touchdowns, while rushing five times for 29 yards.
Who led the Chiefs in receiving?
Travis Kelce led Kansas City with eight receptions for 121 yards and one touchdown.
Who led Arizona in receiving?
Greg Dortch led the Cardinals with seven receptions for 63 yards.
Who led the Chiefs in rushing?
Isiah Pacheco led Kansas City with 12 carries for 62 yards and one touchdown.
What is the Chiefs’ all-time record against the Cardinals?
Kansas City is 10–3–1 against Arizona in 14 regular-season meetings.
Have the Chiefs and Cardinals played in the playoffs?
No. The franchises have zero playoff meetings. Their recorded head-to-head series consists of regular-season games.
When was the last Chiefs vs Cardinals game?
The most recent regular-season meeting was September 11, 2022, when Kansas City won 44–21 in Arizona.
Sources and References
- NFL — Kansas City Chiefs 2022 Schedule — official NFL schedule verification.
- Kansas City Chiefs — 2022 Historical Schedule — official Chiefs game results.
- Kansas City Chiefs — 2022 Game Center — official matchup statistics and scoring data.
- Arizona Cardinals — 2022 Historical Schedule — official Cardinals results.
- Pro Football Reference — Chiefs vs Cardinals Head-to-Head — historical matchup records and scores.
- NFL — Patrick Mahomes Career Statistics — career and season-by-season player statistics.
- Pro Football Reference — 2025 Kansas City Chiefs — latest completed Chiefs season statistics.
- Pro Football Reference — 2025 Arizona Cardinals — latest completed Cardinals season statistics.
